Sorry for the delay, I was out of town. No, I do not recall and nausea that I associated with an outbreak. It does effect my mood. I feel very anxious all the time. And can get quite snappy to people. It completely disrupts my sleep, I'm sure partially from the itching, but even after taking prednisone, and the itching subsides I still feel an overall anxiety that keeps me awake. I usually don't feel back to normal for about 6 weeks |